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Phosphorylation of IGF-IR/InsR is elevated in ER+ breast cancer cells resistant to estrogen deprivation and tamoxifen, possibly due to increased secretion of IGF1/2 in these cells and elevated expression of retinoblastoma-binding protein 2 that inhibits IGFBP4/5 by interacting with ER-NRIP1-HDAC1 complex [107,108,109]

Retrieved from Latif, W., Lambrinos, K

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Limited Human Safety Data : BPC-157 has mostly preclinical evidence, and recent reviews state that well-designed human trials are still needed to assess safety, effectiveness, and clinical value